The Best Cell and Gene Therapy Conferences in 2024What are the best Cell and Gene Therapy conferences to attend in 2024?  We asked our VP of Commercial Lindsey Clarke what her top picks are for the coming year. It really depends on what your reasons are for wanting to...

Data and Digitization – The key to better biology and more effective therapiesData is the cornerstone of any scientific endeavor. But throughout history it’s been managed pretty poorly. Most data ever gathered on cells remain in hand-written lab notebooks, gathering...

Making cell therapies comPATible with large scale manufacturingProcess analytical technologies (PATs) cover a wide range of tools, playing an important role in initiatives such as quality by design (QbD), real-time release, and continuous manufacturing [1]. They are...

How do you solve a problem like scaling up microfluidics?Culturing cells using microfluidics offers several advantages over traditional cell culture techniques – the main one being the ability to precisely control the microenvironment. This means the availability of...

Make your cells feel at home with microfluidicsIt can be easy to forget just how alien an environment in vitro culture is when culturing cells. In vivo, cells exist in a multi-faceted micro-environment made up of a carefully regulated biochemical milieu combined with...

Microfluidics- the perfect meeting-place for viruses and cellsViruses get a bad press. SARS-CoV-2 did little to improve matters, but those of us working in gene and cell therapy are only too aware of the critical role lentiviruses, adeno- and adeno-associated viruses...

Scale up, look sharp – why analytics in large-scale cell therapy manufacture is so difficultCAR-T and other cell and gene therapies represent an exciting new paradigm in how we approach previously untreatable diseases. But as ‘living drugs’ where the cell is the...

Why successful cell therapy processes need to scale both waysWhen it comes to cell therapy manufacturing, much of the industry is focussed on optimizing large scale manufacture – whether that’s scaling up larger batches for allogeneic therapies, or scaling out more...

Is innovation in automation enough to drive cell therapy manufacturing optimization?Moving away from manual handling in large-scale cell therapy manufacturing is undisuptably the next step in optimization. Manual operations are often tricky to replicate between...

Footprint size matters in cell and gene therapy manufacturingCell and gene therapies have demonstrated their extraordinary, curative potential in the last decade. They’ve had the biggest impact in liquid tumors, but with over 1000 clinical trials in the advanced...

How to ensure a consistent cell expansion process? Don’t start at the endCell culture has a culture of measuring endpoints. Vessels used to expand cells (like multi-well plates and flasks) are essentially mystery boxes in the days or weeks of culture. It’s only at the...

New technologies, old methods- Why 99% of cell culture vessels will never scale“We’re entering a new frontier in medical innovation with the ability to reprogram a patient’s own cells to attack a deadly cancer.” That’s what Scott Gottlieb, commissioner of the FDA said...