Blog Articles

Making cell therapies comPATible with large scale manufacturing

Making cell therapies comPATible with large scale manufacturing

Making cell therapies comPATible with large scale manufacturingProcess analytical technologies (PATs) cover a wide range of tools, playing an important role in initiatives such as quality by design (QbD), real-time release, and continuous manufacturing [1]. They are...

How do you solve a problem like scaling up microfluidics?

How do you solve a problem like scaling up microfluidics?

How do you solve a problem like scaling up microfluidics?Culturing cells using microfluidics offers several advantages over traditional cell culture techniques – the main one being the ability to precisely control the microenvironment. This means the availability of...

Make your cells feel at home with microfluidics

Make your cells feel at home with microfluidics

Make your cells feel at home with microfluidicsIt can be easy to forget just how alien an environment in vitro culture is when culturing cells. In vivo, cells exist in a multi-faceted micro-environment made up of a carefully regulated biochemical milieu combined with...

Microfluidics- the perfect meeting-place for viruses and cells

Microfluidics- the perfect meeting-place for viruses and cells

Microfluidics- the perfect meeting-place for viruses and cellsViruses get a bad press. SARS-CoV-2 did little to improve matters, but those of us working in gene and cell therapy are only too aware of the critical role lentiviruses, adeno- and adeno-associated viruses...

Why successful cell therapy processes need to scale both ways

Why successful cell therapy processes need to scale both ways

Why successful cell therapy processes need to scale both waysWhen it comes to cell therapy manufacturing, much of the industry is focussed on optimizing large scale manufacture – whether that’s scaling up larger batches for allogeneic therapies, or scaling out more...

Footprint size matters in cell and gene therapy manufacturing

Footprint size matters in cell and gene therapy manufacturing

Footprint size matters in cell and gene therapy manufacturingCell and gene therapies have demonstrated their extraordinary, curative potential in the last decade. They’ve had the biggest impact in liquid tumors, but with over 1000 clinical trials in the advanced...

How to ensure a consistent cell expansion process

How to ensure a consistent cell expansion process

How to ensure a consistent cell expansion process? Don’t start at the endCell culture has a culture of measuring endpoints. Vessels used to expand cells (like multi-well plates and flasks) are essentially mystery boxes in the days or weeks of culture. It’s only at the...

99 problems in manual cell culture

99 problems in manual cell culture

99 problems in cell research – manual handling is number oneWhen you think of a biologist you probably picture someone pipetting in a lab growing organisms out of a Petri dish. Companies have made fortunes selling glassware, plasticware, and the myriad of equipment...